das Bild ist soch die Schau, oder? Wakefield spielt Luther *g*
Eigentlich müsste the Lancet das Paper jetzt zurückziehen (die Wissenschaft darin glaubt ja schon lange eigentlich keiner mehr). Wakefield sagt, das alles sei ihm nicht peinlich. Wenn das wirklich stimmt, dann ist er strunzdumm!
Catherina
sehr ausführlich zum Thema Impfen und Autismus und Wakefield's sloppy science:
http://www.cispimmunize.org/fam/mmr/a_report.html
...O'Leary et al reported in testimony before the House Government Reform Committee on April 6, 2000, that evidence of measles virus genomic RNA encoding for F and H proteins was found in intestinal wall tissue specimens provided by Wakefield from 24 of 25 children with autism and 1 of 15 children without autism.185 No mention was made as to the genetic sequences of the viruses identified. Further methodologic details necessary for the scientific review of this report have not been published, and the information was not provided in response to a request. Several laboratories have investigated the possible persistence of measles virus in intestinal tissue in IBD.186,187 Iizuka et al188 identified the antigen reacting with the monoclonal antibody used by Wakefield et al179 and demonstrated that the antibody reacts to measles nucleocapsid antigen and to intestinal tissue in patients with Crohn's disease. Iizuka et al identified, isolated, and sequenced the protein in intestinal tissue specimens reacting with this monoclonal antibody and showed that the protein was of human, not measles virus, origin. Iizuka et al also identified the protein in increased amounts in patients with ulcerative colitis or noninflammatory colitis, compared with controls, and they found small numbers of cells containing this protein in esophagus, stomach, duodenum, and lung tissue specimens but not in liver, spleen, kidney, or heart tissue specimens. This group hypothesized that the "measles related antigen" could be the target of an autoantibody generated by measles through molecular mimicry. In a subsequent report, they were unable to detect cross-reacting antibodies to the measles related antigen detected in serum samples from 15 patients with Crohn's disease, 15 with ulcerative colitis, and 15 controls, which does not support the autoimmunity hypothesis.189 Other laboratories were also unable to identify measles antigens in intestinal wall tissue specimens from patients with IBD using sensitive immunohistochemical staining and PCR and reverse-transcriptase PCR (RT-PCR) assays.187,190-194 Chadwick et al,195 working with Wakefield et al, were unable to detect measles virus in intestinal tissue specimens from patients with IBD using PCR assay. Afzal et al186 recently reviewed published studies and concluded that the available data indicate the absence of measles virus in tissue specimens from patients with IBD. However, the studies by Iizuka et al do not resolve the findings of Katamaya et al,149 who found measles nucleoprotein mRNA in 8% to 20% of brain, lung, liver, spleen, and kidney tissue specimens obtained at autopsy using RT-PCR assay. These individuals had no known gastrointestinal or neurologic disorders reported, indicating that measles virus may persist in unaffected tissue. If so, detection of portions of the virus in tissue may be unrelated to local disease. The panel learned of additional unpublished studies by Ward et al (B. Ward, MD, personal communication, June 12 and December 18, 2000) which are purported to reveal the presence of specific transcripts for the nucleocapsid gene of measles as well as another incompletely characterized paramyxovirus in a small number of patients with IBD and a control using degenerate primers and RT-PCR assay. No evidence was found for any other measles gene transcripts. The findings of measles nucleocapsid genomic RNA in affected tissue specimens from patients with otosclerosis196 or Paget's disease197,198 suggests the possibility that nucleocapsid genomic RNA may persist after paramyxovirus infections in some tissues.